实验动物与比较医学2013，Vol.33Issue(4)：290-295,6.DOI:10.3969/j.issn.1674-5817.2013.04.009
β-咔啉类衍生物对BALB/c裸小鼠肝癌皮下移植瘤生长的影响
Effect of β-carboline derivative on Subcutaneous Transplant Hepatocellular Carcinoma Growth in BALB/c Nude Mice
摘要
Abstract
Objective To investigate the effect of (a)-carboline derivative HMD on subcutaneous transplant hepatocellular carcinoma in BALB/c nude mice.Methods A tumor model of human HCC was created by subcutaneous inoculation of 2 × 107 (cells/ml,0.2ml) HepG2 cells into BALB/c male nude mice.The mice were randomized to low-(0.22 mg/kg),medium-(0.44 mg/kg),and high-dose HMD (0.87 mg/kg)group,saline group and 5-Fu group.The mice in each group received iv injection of the drug for 15 days.The effects of HMD on the growth of human hepatocellular carcinoma,the weight and pathological changes of nude mice￡§S main organs were observed.Results Compared with saline group,the mice in HMD groups and 5-Fu group showed significant inhibition in the growth of the transplanted tumor (P＜0.01).The inhibitory rate of HMD on the mouse weight.Compared to the saline group,the inhibitory effects of HMD(0.44,0.87 mg/kg) were of statistic significance (P＜0.01).Contrast to the negative control,there were no significant difference to the weight of kidney and kidney index in HMD groups and 5-Fu group,but there were significant differeces in the weight of liver and liver index (P＜0.05).Conclusion HMD exhibit an inhibitory effect on the growth of transplanted HepG2 tumor,and the mice don't appear toxicity symptom.关键词
β-咔啉类衍生物(HMD)/BALB/c裸小鼠/人肝癌皮下移植瘤/急性毒性实验Key words
β-carboline derivatives(HMD)/ BALB/c nude mice/ Subcutaneous transplanted liver tumor/Acute toxicity分类
生物科学引用本文复制引用
张燕,范文玺,徐艺玫,史深,贵友军,燕顺生..β-咔啉类衍生物对BALB/c裸小鼠肝癌皮下移植瘤生长的影响[J].实验动物与比较医学,2013,33(4):290-295,6.基金项目
新疆维吾尔自治区公益性科研院所基本科研业务经费资助项目(KY2012084) （KY2012084）
