生物信息学2013，Vol.11Issue(2)：146-149,4.DOI:10.3969/j.issn.1672-5565.2013.02.13
结构方程混合模型在SNP分析中的应用
Structural equation mixture modeling and their application in analysis of SNP
摘要
Abstract
To analyze SNP data of GAW17 by Structural equation mixture modeling(SEMM),and to provide a new method for the study of genetic statistic.The data is provided by GAW17,it contains 697 individual,22 autonomic tens of thousands of SNP and the SNP simulated 697 individual trait characteristics.In this study,randomly selected the four SNP from chromosome 1 and three quantitative traits as a research variable,which were analysised by latent class and mixed structural equation modeling.According to four SNP data,the crowd was divided into three potential categories,each category probability were 0.53,0.34,0.13.Factors mean Q of latent class 1,2 and 3 are-4.029,-2.052 and 0.We knew that factor mean of latent class 1,2 are lower than 3(＜0.001).So we have reasons to think that structural equation mixed modeling integrated the structural equation modeling and latent class modeling thoughts,formed its own advantage,which can be used for processing classification latent variable and continuous latent variable data.关键词
结构方程混合模型(SEMM)/单核苷酸多态性(SNP)/连续潜变量/分类潜变量Key words
Structural Equation Mixture Modeling(SEMM)/ SNP/ Continuous Latent /Categorical Latent分类
生物科学引用本文复制引用
杨圆圆,贾志杰,李治,罗艳虹,张岩波..结构方程混合模型在SNP分析中的应用[J].生物信息学,2013,11(2):146-149,4.基金项目
国家自然科学基金资助项目(31071156). （31071156）
