实用妇产科杂志2013，Vol.29Issue(6)：450-453,4.
妊娠期糖尿病患者视黄醇结合蛋白4的变化及其与血糖和血脂的代谢关系
The Change of Serum Retinol Binding Protein 4 and Its Relationship with Blood Glucose and Lipid Metabolism in Patients with Gestational Diabetes Mellitus
薛丽丽 1陈丹青2
作者信息
- 1. 浙江大学医学院附属妇产科医院,浙江杭州310000
- 2. 浙江省嘉兴市妇幼保健院,浙江嘉兴314000
- 折叠
摘要
Abstract
Objective:To explore the change of serum retinol binding protein 4 (RBP4) and its relationship with blood glucose and lipid metabolism in patients with gestational diabetes mellitus(GDM) by oral glucose tolerance test (OGTT).Methods:35 pregnant women with GDM who undertook antenatal check in Women's Hospital School of Medicine Zhejiang University from May 2008 to May 2010 were included in GDM group,and 35 normal pregnant women in the same period were included as controls.The fasting serum concentrations of RBP4,serum levels of fasting insulin (FINS),serum triglyceride (TG) and total cholesterole (TC) were measured in all subiects at OGT-T.Person analysis was used to analyzed the correlation between serumRBP4 and the above indexes.Results:①There was no significant difference in fasting,3-hour postprandial sugar and HbA1c levels between these two groups (P ＞ 0.05) ;The serum concentrations of RBP4 in GDM group was significantly higher compared with control group(P＜0.01).②The serum RBP4,TC,TG,fasting insulin levels and HOMA-IR in GDM group were significantly higher than those in control group (P＜0.05).③There were no correlations between the fasting plasma glucose,fasting insulin and HbA1 c and the serum concentrations of RBP4 in both groups; However,in GDM group the serum concentrations of RBP4 were positively correlated with plasma glucose after 1 hour and 2 hour at OGTT、TG、TC and HOMA-IR(r=0.523、0.521、0.490、0.620、0.486,P ＜ 0.05).Conclusions:The elevation of the concentrations of serum RBP4 at OGTT is involved in the glucose and lipid metabolism disregulation and IR in the patients with GDM.关键词
妊娠期糖尿病/视黄醇结合蛋白4/血糖/血脂/胰岛素抵抗Key words
Gestational diabetes mellitus/Retinol binding protein 4/Glucose/Lipid/Insulin resistance分类
医药卫生引用本文复制引用
薛丽丽,陈丹青..妊娠期糖尿病患者视黄醇结合蛋白4的变化及其与血糖和血脂的代谢关系[J].实用妇产科杂志,2013,29(6):450-453,4.
