摘要
Abstract
Objective To observe the changes of peripheral blood T lymphocyte subsets and serum cytokine levels in patients with chronic hepatitis B receiving lamivudine and kurorinone treatment.Methods 86 patients with chronic hepatitis B were randomly divided into two groups.Forty-two patients were treated with lamivudine and kurorinone,a herbal medicine,for 48 weeks,and forty-four with lamivudine alone for 48 weeks.At the end of the observation,we detected the serum levels of cytokines by ELISA and the proportion of T lymphocyte subsets in blood by Facs.Results At the end of 48 weeks,serum levels of IL-2 in combination and lamivudine group were 181.1±26.1pg/ml and 86.9±10.7pg/ml(P＜0.05),the levels of IFN-γ were 47.5±4.3pg/ml and 27.8±4.4pg/ml(P＜0.05),the levels of IL-6 were 13.2±5.8pg/ml and 27.1±6.4pg/ml (P＜0.05),and the levels of IL-10 were 109.7±32.1 pg/ml and 169.5±36.2pg/ml(P＜0.05),respectively ;the proportion of CD4+ T lymphocytes were 37.2±5,8％ and 27.8±6.4％(P＜0.05),the proportion of CD8+ were 20.8±5.2％ and 26.3±6.2％(P＜0.05),and the CD4+/CD8+ ratio in the two groups were 1.56±0.3 and 1.34±0.2 (P＜0.05),respectively.Conclusion The combination of lamivudine and kurorinone could modulate Th1/Th2 cytokines by changing the proportions of T lymphocyte subsets.关键词
慢性乙型肝炎/拉米夫定/苦参素/细胞因子/T细胞亚群Key words
Hepatitis B/Lamivudine/Kurorinone/Cytokines/T lymphocyte subset
