实用医学杂志2013，Vol.29Issue(9)：1429-1431,3.DOI:10.3969/j.issn.1006-5725.2013.09.018
阿尔茨海默病、血管性痴呆及轻度认知障碍患者血浆脑源性神经营养因子浓度变化
Study of plasma concentration of brain-derived neurotrophic factor in patients with alzheimer disease,vascular dementia and mild cognitive impairment
摘要
Abstract
Objective To investigate the relation of alzheimer disease (AD),vascular dementia (VD) and mild cognitive impairment (MCI) with plasma brain-derived neurotrophic factor (BDNF).Methods All subjects included 50 MCI,45 AD,30 VD and 40 healthy elderly.The concentration of BDNF were tested by enzyme-linked immunosorbent assay (ELISA).Results BDNF concentrations were significant different in MCI group (6.2 ± 5.1)μg/L,AD group (8.1 ± 5.0) μg/L,VD group (5.6 ± 4.8) μg/L,compared with control group (6.4 ± 3.1) μg/L (P =0.013),and BDNF concentrations in AD group was higher than MCI and VD groups (P ＜ 0.05).There were significant differences between moderate-to-severe AD group and MCI group (P =0.023).There were no significant correlation between BDNF concentration and gender,age,duration,stroke frequency,MMSE score,CDR score and ADL score in all groups.Conclusions Plasma BDNF concentration in AD group were higher than MCI and VD groups,but BDNF concentration were not related with the course of disease course and cognitive impairment in the three groups.关键词
阿尔茨海默病/血管性痴呆/轻度认知障碍/脑源性神经营养因子Key words
Alzheimer disease/Dementia,vascular/Mild cognitive impairment/Brain-derived neurotrophic factor引用本文复制引用
郁俊昌,唐牟尼,韩海英,王华成..阿尔茨海默病、血管性痴呆及轻度认知障碍患者血浆脑源性神经营养因子浓度变化[J].实用医学杂志,2013,29(9):1429-1431,3.基金项目
广州市医药卫生科技项目(编号:2009-YB-108) （编号:2009-YB-108）
