实用医学杂志2013，Vol.29Issue(9)：1497-1499,3.DOI:10.3969/j.issn.1006-5725.2013.09.046
辛伐他汀对左室肥厚和左室功能的影响
Left ventricular hypertrophy and left ventricular function in essential hypertensive patients receiving telmisartan-based therapy with or without simvastatin
摘要
Abstract
Objective To evaluate the changes of left ventricular hypertrophy and left ventricular function in essential hypertensive patients receiving telmisartan-based therapy with or without simvastatin.Method Forty-one patients with essential hypertension combined with left ventricular hypertrophy were randomized into the control group (Group N),the telmisartan-based therapy group,and the telmisartan-based plus simvastatin therapy group (Group T).The study period lasted for one year.Result (1) The blood pressure of the patients with simple essential hypertension combined with left ventricular hypertrophy was high; (2) The telmisartan-based plus simvastatin therapy was more effective in decreasing the systolic blood pressure than group N; (3)Mer 1-year treatment,the parameters of left ventricular hypertrophy in both two groups were improved,and the ejection fraction was elevated more significantly in group T than that in group N (57.50 ± 16.41％ vs 65.43 ± 11.60％,P ＜ 0.01).The left ventricular hypertrophy was ameliorated and the left ventricular systolic function was improved markedly in group T; (4) The left atrium inner diameter in group T was significantly decreased (P ＜0.01),and the ratio of E/A and the left ventricular systolic function were also reduced in group T.Conclusion Simvastatin treatment could efficiently ameliorate left ventricular hypertrophy and improve the left ventricular systolic function,but it has no benefit of improving the left ventricular diastolic function.关键词
高血压/辛伐他汀/心肌肥厚/左室收缩功能/左室舒张功能Key words
Hypertension/Simvastatin/Left ventricular hypertrophy/Left ventricular systolic function/Left ventricular diastolic function引用本文复制引用
卜彤,潘秀娣,曾昭华,温燕杭,肖霭仪,陆东风..辛伐他汀对左室肥厚和左室功能的影响[J].实用医学杂志,2013,29(9):1497-1499,3.基金项目
国家自然科学基金(编号:81170280) （编号:81170280）
广州市科技局基金资助项目(编号:2006C13G0021) （编号:2006C13G0021）
