实用医学杂志2013，Vol.29Issue(10)：1637-1639,3.DOI:10.3969/j.issn.1006-5725.2013.10.037
丙氨酸氨基转移酶正常慢性乙型肝炎病毒感染者肝组织病理特点
Pathological features of liver tissues in chronic HBV carriers with normal level of alanine aminotransferase
朱海超 1高国生2
作者信息
- 1. 473135 南阳医专第一附属医院肝病科
- 2. 315010 宁波市传染病医院
- 折叠
摘要
Abstract
Objective To study the liver pathological changes of chronic HBV cariers with normal alanine aminotransferase (ALT) level and its relationships with erum HBV-DNA and serum HBeAg.Methods 138 cases of chronic HBV cariers with normal ALT level were retrospectively analyzed.Histopathologic examinations for liver tissues were performed in all patients,and the serum HBV-DNA and hepatitis B markers were also detected.Results Of all the cases,only 5.1％ of them were found to be normal using pathological examination,31.9％ of them with inflammation or fibrosis (≥ G2 or ≥ S2).No significantly difference (P ＞ 0.05) in the grades of inflammation or fibrosis was found between HBeAg (+) group and HBeAg (-) group.Among the HBeAg (-) cases,the rate of the patients (HBV-DNA ≥ 10 000 IU/ml)with significant inflammation and fibrosis were 60％ and 73.3％,respectively,and were of,significantly higher (P ＜ 0.05) than that of patients in the group (HBV-DNA ＜10 000 IU/ml).Conclusion Inflammation and fibrosis were found in liver tissues of most chronie HBV cariers with normal ALT level.Significant liver tissue lesions were detected in one third of them and antiviral therapy need to be used for these patients.The patients with HBeAg negative and HBV-DNA ≥ 10 000 IU/mL should be examined using liver biopsies and then to be treated in time.关键词
丙氨酸氨基转移酶/慢性乙型肝炎病毒感染/肝活检/病理Key words
Alanine aminotransferase/Chronic HBV cariers/Liver biopsy/Pathology引用本文复制引用
朱海超,高国生..丙氨酸氨基转移酶正常慢性乙型肝炎病毒感染者肝组织病理特点[J].实用医学杂志,2013,29(10):1637-1639,3.
