中国动脉硬化杂志2013，Vol.21Issue(7)：650-655,6.
替罗非班在急性ST段抬高型心肌梗死经皮冠状动脉介入治疗前应用的Meta分析
Meta-analysis of the Application of Tirofiban Before Percutaneous Coronary Intervention Treatment in Patients with Acute ST-segment Elevation Myocardial Infarction
张林叶 1方五旺 1柏战 1王宗方 1杨洋1
作者信息
- 1. 芜湖市第二人民医院心内科,安徽省芜湖市241000
- 折叠
摘要
Abstract
Aim To evaluate the efficacy and safety of the application of tirofiban in acute ST-segment elevation myocardial infarction (STEMI) patients before percutaneous coronary intervention (PCI) treatment.Methods We performed systematic searches of MEDLINE,EMBASE,and CENTRAL databases for randomized controlled trials (RCT) of tirofiban use in STEMI patients treated with aspirin and clopidogrel which reported clinical outcomes after primary PCI.Statistical analysis was conducted with RevMan 5.0.Results Four randomized controlled trials were eligible for the inclusion,involving 811 patients in tirofiban group and 813 control subjects.The application of PCI,prior to the treatment of STEMI,the routine use of tirofiban major adverse cardiovascular events (MACE) within 30 days decreased (RR =0.63,95％ CI was 0.44 ～ 0.90,P =0.001) ; all-cause mortality incidences declined (RR =0.61,95％ CI was 0.35 ～1.05,P =0.007) ; re-myocardial infarction incidences were not significantly different between the two groups (RR =0.67,95％ CI was 0.34 ～1.31,P =0.24); there were no significant differences in the incidences of serious bleeding (RR =1.21,95％ CI was 0.67 ～ 2.16,P =0.53).Conclusions Current analysis of available studies suggests that routine and early tirofiban use before primary PCI may decrease the major cardiovascular events within 30 days in STEMI patients treated with aspirin and clopidogrel without any significant increase in major bleeding.关键词
替罗非班/急性ST段抬高型心肌梗死/经皮冠状动脉介入/Meta分析Key words
Tirofiban/ Acute ST-segment Elevation Myocardial Infarction/ Percutaneous Coronary Intervention/ Meta-analysis分类
医药卫生引用本文复制引用
张林叶,方五旺,柏战,王宗方,杨洋..替罗非班在急性ST段抬高型心肌梗死经皮冠状动脉介入治疗前应用的Meta分析[J].中国动脉硬化杂志,2013,21(7):650-655,6.
