中国药房2013，Vol.24Issue(31)：2884-2886,3.DOI:10.6039/j.issn.1001-0408.2013.31.02
见血青提取物止血作用的实验研究
Study on the Hemostatic Effect of the Extracts from Liparis nervosa
摘要
Abstract
To study the effect of Liparis nervosa on promoting hemostasis and blood coagulation.METHODS:The mice were given high-dose and low-dose(4,2 g/kg) aqueous extract,aether petrolei extract,dichloromethane extract,water extraction and alcohol precipitation of L.nervosa intragastrically once a day for consecutive 7 days.The bleeding time (BT) was determined by shearing tail method.Clotting time(CT) was detemined by capillary tube method.The rats were given high-dose and low-dose(4,2 g/kg) aqueous extract,aether petrolei extract,dichloromethane extract,water extraction and alcohol precipitation of L.nervosa intragastrically once a day for consecutive 7 days.The blood samples were collected from carotid artery for the determination of prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT) and fibrinogen (FIB).RESULTS:High-dose and low-dose dichloromethane extract of L.nervosa could shorten BT of mice significantly(P＜0.05) ;CT and the APTT values were obviously shortened by low-dose dichloromethane extract(P＜0.05),and FIB values were obviously increased by all of the extracts of L.nervosa(P＜0.05).CONCLUSIONS:L.nervosa has an effect on promoting hemostasis and blood coagulation,and its mechanisms may be related with shrinking blood vessels,inhibiting plasmin activity and rising FIB content.关键词
见血青/止血/止血时间/凝血时间/纤维蛋白原Key words
Liparis nervosa/Hemostatic effects/Bleeding time/Clotting time/Fibrinogen分类
医药卫生引用本文复制引用
赵颖,胡少南,郑一敏,胥秀英..见血青提取物止血作用的实验研究[J].中国药房,2013,24(31):2884-2886,3.基金项目
重庆市教委科学技术研究项目(No.2011CJ02) （No.2011CJ02）
重庆理工大学科研启动基金资助项目(No.2010ZD07) （No.2010ZD07）
