中国医科大学学报2013，Vol.42Issue(8)：693-696,4.
普罗布考对阿霉素肾病大鼠足细胞nephrin和podocin表达的影响
Effects of Probucol on Podocin and Nephrin Expression in Rats with Adriamycin-induced Nephrosis
摘要
Abstract
Objective To study the effects of probucol on podocin and nephrin expression in rats with adriamycin-induced nephrosis.Methods A total of 36 SD rats were randomly divided into three groups:control group (CG group,n =12),nephrosis group (NS group,n =12) and probucol group (NSP group,n =12).The nephrosis models were established by caudal vein injection of adriamycin.Twenty-four h urine protein quantification was performed at the end of the forth week.Light microscope was employed to investigate the pathological changes of the glomerulus,Western blot was carried out to determine the protein expression of podocin and nephrin.Results Twenty-four h urine protein was significantly increased in NS group and NSP group compared with the CG rats (P ＜ 0.05),and less urinary protein was detected in NSP group than in NS group (P ＜ 0.05).Protein expression of nephrin and podocin was significantly decreased in NS and NSP rats than in CG rats (P ＜ 0.05),while protein expression of these two components was up-regulated in NSP rats compared with the NS rats (P ＜0.05).Conclusion Probucol may achieve the protective effect on adriamycin-induced nephrosis by relieving the podocyte injury.关键词
普罗布考/阿霉素/足细胞/podocin/nephrinKey words
probucol/ adriamycin / podocyte / podocin / nephrin分类
医药卫生引用本文复制引用
杜丰,苏雪松,周光宇,何平,刘波,李德天..普罗布考对阿霉素肾病大鼠足细胞nephrin和podocin表达的影响[J].中国医科大学学报,2013,42(8):693-696,4.基金项目
辽宁省教育厅高校科研计划(L2010581) （L2010581）
