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尾加压素及其受体在大鼠肺缺血-再灌注损伤中的表达

马立民 饶旭光 段明科 杨伟 黎佩剑

中国医药科学Issue(15):24-25,2.
中国医药科学Issue(15):24-25,2.

尾加压素及其受体在大鼠肺缺血-再灌注损伤中的表达

Expression of urotensinⅡand its receptors during ischemia-reperfusion injury in rats in vivo

马立民 1饶旭光 1段明科 2杨伟 1黎佩剑3

作者信息

  • 1. 汕头大学医学院第二附属医院胸心外科,广东汕头515040
  • 2. 厦门市第二医院胸心外科,福建厦门361000
  • 3. 广东省惠州市中心人民医院胸心外科,广东惠州516000
  • 折叠

摘要

Abstract

  Objective To investigate the expression of urotensin Ⅱ and its receptors during ischemia-reperfusion injury in rats. Methods Using IHC to observe the levels of UII and UT of rat pulmonary tissues and Using ELISA to observe the levels of U Ⅱ and UT of rat pulmonary tissues in different groups. Results U Ⅱ and UT was widely distributed in a variety of pulmonary cells.Its expression was boosted in pulmonary tissues and plasma after appearance of ischemia and reperfusion,especially in reperfusion stage,ischemia,reperfusion and up-regulation the expression of UT. Conclusion Ischemia and reperfusion can promote lung tissue cells to synthesize and excrete release U Ⅱ.

关键词

尾加压素/受体/缺血-再灌注损伤/

Key words

Urotensin Ⅱ/Receptors/Ischemia-reperfusion injury/Lung

分类

医药卫生

引用本文复制引用

马立民,饶旭光,段明科,杨伟,黎佩剑..尾加压素及其受体在大鼠肺缺血-再灌注损伤中的表达[J].中国医药科学,2012,(15):24-25,2.

基金项目

广东省医学科研基金资助项目(A2008454) (A2008454)

中国医药科学

2095-0616

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