肿瘤防治研究2013，Vol.40Issue(8)：767-771,5.DOI:10.3971/j.issn.1000-8578.2013.08.010
鼻咽癌患者调强放疗过程中体重变化及影响因素分析
Analysis of Body Weight Loss and Influence Factors During Intensity-modulated Radiotherapy for Patients with Nasopharyngeal Carcinoma
摘要
Abstract
Objective To investigate body weight loss and influence factors during intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).Methods To explore body weight and BMI variation and influence factors,body weight and body mass index (BMI) change analysis were done retrospectively for 57 NPC patients during IMRT.Results In 57 NPC patients treated by IMRT,the pre radiotherapy and post-radiotherapy average body weight were (60.4 ± 9.4)kg and (55.1 ±8.7)kg (P=0.0025),body weight loss ranged from 17 kg to-0.5 kg,and average BMI of pre-radiotherapy and post-radiotherapy were (22.8 ± 3.5)kg/m2,(20.8 ± 3.1)kg/m2 (P =0.0017),ranged from 6.0 kg/m2 to-0.2 kg/m2,respectively.To the end of radiotherapy,93.0％ patients lost weight at different levels,the mean percentage of weight loss was 8.4％ and ranged from 23.4％ to-0.7％,35.1％ patients lost weight over 10％ and 68.4％ patients lost weight over 5.0％.Univariate multi-factor analysis of variance showed that the WHO pathological grade,AJCC6th stage,performance status (PS),concurrent chemotherapy and late course accelerated hyperfractionated radiotherapy (LCAFR) had no statistical influence on body weight and BMI loss,but patients with age older than 50 years or BMI greater than 25 kg/m2 or body weight more than 60 kg lost body weight and BMI more than others (P＜0.05).Linear regression analysis showed that average radiation dose weekly and the average body weight weekly were significantly negatively correlated (R2 =-0.996,P ＜0.001).Conclusion Body weight loss is widespread in NPC patients during IMRT.The age,pre-radiotherapy body weight and BMI,radiation dose maybe have more impact on body weight and BMI loss significantly rather than the gender,WHO pathological grade,AJCC6thstage,performance status,concurrent chemotherapy and late course accelerated hyperfractionated radiotherapy in NPC patients with IMRT.关键词
鼻咽癌/调强放疗/体重/体质指数/营养Key words
Nasopharyngeal carcinoma/Intensity-modulated radiotherapy/Body weight/Body mass index/Nutrition分类
医药卫生引用本文复制引用
程金建,杨华,陆合明,蒿艳蓉,卢志平,陈甲信..鼻咽癌患者调强放疗过程中体重变化及影响因素分析[J].肿瘤防治研究,2013,40(8):767-771,5.基金项目
国家自然科学基金资助项目(81160284) （81160284）
