肿瘤防治研究2013，Vol.40Issue(8)：781-785,5.DOI:10.3971/j.issn.1000-8578.2013.08.013
MUC1在不同免疫表型乳腺癌组织中的强阳性表达及其与预后的关系
Strongly Positive Expression of MUC1 and Its Relationship with Prognosis in Different Immunophenotypes of Breast Cancer Tissues
摘要
Abstract
Objective To explore the clinical significance of strongly positive expression (+ + +) of mucin1 (MUC1) for prognosis and individual treatment in different immunophenotypes of breast cancer.Methods Three hurdred and thirty-five cases of breast cancer were categorized as follows:ER +/PR +,HER2-; ER +/PR +,HER2 + ; ER-,PR-,HER2 + and ER-,PR-,HER2-subtype.The expression levels of ER,PR,HER2 and MUC1 were detected by mean of immunohistochemistry and the relationship between the strongly positive expression of MUC1 and prognosis of breast cancer was analyzed.Results The strongly positive rate of MUC1 in 335 cases was 46.3 ％,5-year overall survival rates(OS) of patients with strongly positive expression of MUC1 was lower (P＜0.05).In 335 cases,ER +/PR +,HER2-subtype was 130,ER +/PR +,HER2 + subtype was 64,ER-,PR-,HER2 + subtype was 67 and ER-,PR-,HER2 subtype was 74.The strongly positive rate of MUC1 of four subtypes was 59.2％、56.3％、32.8％ and 27.0％,respectively.The strongly positive rate of MUC1 has related tothe immunophenotypes of breast cancer(P＜0.01).5-year overall survival rates(OS) of patients with strongly positive expression of MUC1 was lower in ER +/PR +,HER2-and ER-,PR-,HER2 + subtype (P＜0.05)by group analysis of prognosis.Conclusion The strongly positive expression of MUC1 was related to the immunophenotypes of breast cancer and played different role in prognosis of different immunophenotypes of breast cancer.The prognosis of patients with MUC1 strongly positive expression was poorer in ER + /PR +,HER2-and ER-,PR-,HER2 + subtype.关键词
乳腺癌/黏蛋白1/免疫表型/预后/免疫组织化学Key words
Breast cancer/Mucin 1/Immunophenotype/Prognosis/Immunohistochemistry分类
医药卫生引用本文复制引用
谢轶群,包家林,徐明,裔海鹰,黄雷..MUC1在不同免疫表型乳腺癌组织中的强阳性表达及其与预后的关系[J].肿瘤防治研究,2013,40(8):781-785,5.基金项目
上海首批青年医师培养资助计划资助项目(沪卫人事[2012]105号) （沪卫人事[2012]105号）
上海市黄浦区卫生事业发展奖励金资助项目(HWY-07156) （HWY-07156）
