肿瘤防治研究2013，Vol.40Issue(8)：793-797,5.DOI:10.3971/j.issn.1000-8578.2013.08.016
两种用药途径在局部晚期宫颈癌新辅助化疗中疗效比较的Meta分析
Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer: A Meta Analysis on Efficacy Comparing of Two Approaches of Route of Administration
韦羽梅 1姚德生 1卢艳1
作者信息
- 1. 530021南宁,广西医科大学附属肿瘤医院妇瘤科
- 折叠
摘要
Abstract
Objective To assess the therapeutic effect of two different approaches of neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer patients.Methods We searched the MEDLINE,Chinese Journal Full-text Database (CNKI) and WanFang Database,and then took a quadratic search on the references,retrieval time was before July 2012,we run a quality assessment and Meta-analysis on the randomized controlled trials which met the inclusion criteria.Results Twelve researches of 765 patients were met the criterion ultimately,including 389 cases of intra-arterial chemoembolization group (arterial group) and 376 cases of intra-venous chemotharopy group (venous group).Meta-analysis results showed that the complete remission rate and total efficiency were greater in arterial one than in the intravenous group,the differences in efficacy were statistically significant.Vasclar invasion,lymph node metastasis and parametrial infiltration in artery group were less than in vein group,with statistically significant,whereas the partial remission rate showed no difference between two approaches.Conclusion Considering the therapeutic effect,safety and poor prognosis factors,patients with locally advanced cervical carcinoma may be more easily benefit from intra-arterial chemoembolization pathway.关键词
宫颈癌/新辅助化疗/动脉灌注化疗/Meta分析Key words
Cervical cancer/Neoadjuvant chemotherapy/Intra-arterial chemoembolization/Meta-analysis分类
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韦羽梅,姚德生,卢艳..两种用药途径在局部晚期宫颈癌新辅助化疗中疗效比较的Meta分析[J].肿瘤防治研究,2013,40(8):793-797,5.
