维生素E对顺铂所致的小鼠肾毒性的影响及其机制研究OA

　　Objective To investigate the effects of vitamin E on cisplatin induced nephrotoxicity in mice and its mechanism. Methods 10 mg·kg-1 cisplatin was used to induce nephrotoxicity in mice by intraperitoneal injection, and 48 h later, 250 mg·kg-1 and 500 mg·kg-1 vitamin E were respectively used. Then at 72 h after cisplatin treatment, the serum level of urea nitrogen and creatinine were detected to evaluate the change of renal function, and the activities of ma…查看全部>>