北京生物医学工程2013，Vol.32Issue(4)：401-407,7.DOI:10.3969/j.issn.1002-3208.2013.04.14
晚期糖基化终产物受体基因多态性与空腹血糖水平的关联研究
An association study between receptor for advanced glycation endproducts gene polymorphisms and fasting blood glucose level
摘要
Abstract
To evaluate the association between three single nucleotide polymorphisms of receptor for advanced glycation endproducts gene and hyperglycemia in Han Chinese population.Methods Totally 2731 adult subjects aged 18-62 were recruited from a rural population of 14469 subjects in Jiangsu Province by an epidemiological stratification sampling approach and epidemiological data and serum glucose were collected and detected.Linkage disequilibrium (LD) analysis were applied and three tagging single nucleotide polymorphisms (tagSNPs) of RAGE gene (rs1800624,rs204993,rs184003) were selected for genotyping and analyzing for the association with fasting blood glucose level.Results Further adjusted for confounding factors including age,sex,physical activity index and body mass index,no statistical significant difference was detected in the distribution of genotypes for SNP rs1800624,rs204993 and rs184003 between cases and controls.And there was no significant glucose difference among genotype variations of rs1800624,rs204993 and rs184003.Further stratification analysis by sex showed that there was statistical significant difference of glucose level among genotype variations of SNP rs184003 in male.Conclusions Our result suggests that SNP rs1800624,rs204993 and rs184003 of RAGE gene are not associated with increased risk of hyperglycemia in Han Chinese men and further replication study would be warranted.关键词
晚期糖基化终产物受体/基因/血糖/关联研究Key words
receptor for advanced glycation endproducts / gene / glucose / association study分类
医药卫生引用本文复制引用
黄福华,王滢,杨松,陈金凤,王海茹,赵彦平,赵祥海,陈燕春,李莉..晚期糖基化终产物受体基因多态性与空腹血糖水平的关联研究[J].北京生物医学工程,2013,32(4):401-407,7.基金项目
江苏省自然科学基金项目(BK2011776)、南京市医学科技发展项目(KF2009150)、江苏高校优势学科建设工程项目资助 （BK2011776）
