重庆医学2013，Vol.42Issue(19)：2228-2230,3.DOI:10.3969/j.issn.1671-8348.2013.19.016
老年冠心病患者麻醉诱导时艾司洛尔对QT间期的影响
The effect of esmolol on QT interval during induction of anaesthesia in elderly patients with coronary heart disease
秦艳平 1周康华 1温迎春1
作者信息
- 1. 重庆市万州区人民医院麻醉科 404000
- 折叠
摘要
Abstract
Objective To evaluate whether esmolol has an effect on QT interval during induction of anaesthesia in patients with coronary artery disease.Methods Patients aged with coronary artery disease were prospectively randomised to control group and the treatment group.Esmolol was administered as a bolus 0.5 mg · kg-1,followed by a continuous infusion at 25 μg · kg-1 ·min-1.All patients received midazolam 0.1 mg · kg-1 and fentanyl 6 μg · kg-1.The ECG was recorded prior to induction of anaesthesia(T0),5 min following the start of drμg infusions(T1),1 min following midazolam(T2),5 min following vecuronium(T3),30 s (T4),2 min(T5) and 4 min(T6) after intubation.Results In the esmolol group,QTc interval was significantly shorter at T1,T2 and T4 compared to the control group,which was significantly different(P＜0.05).Conclusion QTc interval increased following tracheal intubation during induction of anaesthesia using midazolam and fentanyl in patients with coronary heart disease.An intravenous injection of esmolol could shorten the QTc interval prolongation caused by tracheal intubation.关键词
冠心病/β-受体阻滞剂/QT间期/艾司洛尔Key words
coronary disease / β-receptor blocker / esmolol/ QT interval/ esmolol引用本文复制引用
秦艳平,周康华,温迎春..老年冠心病患者麻醉诱导时艾司洛尔对QT间期的影响[J].重庆医学,2013,42(19):2228-2230,3.
