儿科药学杂志2013，Vol.19Issue(8)：15-17,3.
持续静脉注射咪达唑仑联合静脉注射芬太尼在机械通气患儿的应用
The Sedative Effects of Midazolam Combined with Fentanyl on Children with Mechanical Ventilation
马燕 1刘纯义1
作者信息
- 1. 广东省深圳市宝安区妇幼保健院,广东深圳518133
- 折叠
摘要
Abstract
Objective:To observe the sedative and analgesia effect of midazolam and fentanyl on children who was on mechanical ventilation in PICU.Methods:Forty children undergoing mechanical ventilation were assigned into two groups randomly.The midazolam group (M group,n=20) received midazolam continuously by microinfusion pump.The midazolam and fentanyl group (M+F group,n =20) were given fentanyl injection intravenously and intermittently in addition with midazolam.Both groups maintained Ramsay 3 ～ 4 level.Results:The sedation efficiency between M group and M+F group was not significant (P＞0.05).The amount of midazolam used at 48 hour in M + F group (85.3 ±7.8) μg/kg was significantly lower than that in M group (115.8 ± 9.6) μg/kg.The time for recovery of consciousness between the two groups was not significant (P＞0.05).The time to extubation in M+F group (91 ± 15) min was shorter than that in M group (120± 19) min (P＜0.05).In M+F group,the heart rate,respiration rate and oxygenation index were significandy improved compared with M group.Conclusions:It can provide satisfactory sedation by using continuous midazolam injection intravenously and intermittent fentanyl during mechanical ventilation in PICU.关键词
机械通气/咪达唑仑/芬太尼Key words
Mechanical ventilation / Midazolam/ Fentanyl分类
医药卫生引用本文复制引用
马燕,刘纯义..持续静脉注射咪达唑仑联合静脉注射芬太尼在机械通气患儿的应用[J].儿科药学杂志,2013,19(8):15-17,3.
