广东牙病防治2013，Vol.21Issue(8)：401-403,3.
RUNX2突变牙髓细胞转化生长因子-β相关信号通路基因表达的分析
Effect of RUNX2 mutation on tranforming grouth factor-β relevant signal passway in dental pulp cells
摘要
Abstract
Objective To investigate different expression profile of TGF-β/BMP signaling pathway in dental pulp cells with mutation of RUNX2 gene by PCR array.Methods The dental pulp cells with mutation of RUNX2 gene had been successfully separated and identified in the patients with cleidocranial dysplasia,which was compared with the corre-sponding normal dental pulp cells,and the different gene profile was detected by PCR array about TGF-β/BMP signaling pathway,then data was analyzed.Results The data analysis of PCR array showed that there were 18 genes which were up-regulated in dental pulp cells with mutation of RUNX2 gene compared with normal ones,and 14 genes were down-regulated.Conclnsion The characteristics of dental pulp cells was affected by the related genes about TGF-β/BMP signaling pathway regulated by RUNX2 gene.关键词
牙髓细胞/RUNX2基因/基因突变/基因芯片Key words
Dental pulp cells/ RUNX2 gene/ Gene mutation/ Array分类
生物科学引用本文复制引用
轩东英,谢宝仪,章锦才..RUNX2突变牙髓细胞转化生长因子-β相关信号通路基因表达的分析[J].广东牙病防治,2013,21(8):401-403,3.基金项目
国家自然科学基金面上项目(81271160) （81271160）
广东省医学科学技术研究基金(A2012106) （A2012106）
