江苏大学学报（医学版）2013，Vol.23Issue(4)：341-344,4.
2型糖尿病合并代谢综合征患者血清chemerin水平与超敏C反应蛋白的相关性
Association of serum chemerin with high sensitive C-reactive protein in type 2 diabetes with metabolic syndrome
摘要
Abstract
To investigate serum levels of chemerin in patients with type 2 diabetes mellitus (T2DM) with metabolic syndrome(MS),and to study the association between serum levels of chemerin and highly sensitive C-reactive protein (hs-CRP).Methods:A total of 88 cases were selected,including 28 healthy subjects and 60 T2DM patients which were divided into MS group and non-MS group according to the diagnostic criteria of MS.Oral glucose tolerance test and insulin releasing test were performed,meanwhile,blood lipid,serum chemerin,hs-CRP and other items were measured.Results:Compared with normal control group and non-MS group,the serum chemerin was significantly increased in MS group[(86.47±23.61) vs (60.09 ± 15.32) ng/mL,(86.47 ±23.61) vs (61.16 ± 17.90) ng/mL,P ＜0.01,respectively] ; The serum hs-CRP in MS group was higher than in non-MS group [(2.57 ± 1.64) vs (0.98 ±0.90) mg/L,P ＜0.01].Serum chemerin level was positively correlated with body mass index(BMI),waist circumference (WC),waist hip ratio (WHR),diastolic blood pressure (DBP),Fasting insulin (FINS),postprandial serum insulin(PSI),HOMA-IR,HOMA-β,triglyceride and hs-CRP,and negatively correlated with fasting plasma glucose(FPG),postprandial plasma glucose(2hPG),HDL-C.The multiple regression analysis showed hs-CRP,WHR,DBP and HOMA-β were independent related factors in the influence of the serum chemerin levels.Conclusion:T2DM patients with MS tend to have higher serum chemerin and the level of serum chemerin was associated with hs-CRP.关键词
2型糖尿病/代谢综合征/chemerin/超敏C反应蛋白Key words
type 2 diabetes mellitus/ metabolic syndrome/ chemerin/ highly sensitive C-reactive protein分类
医药卫生引用本文复制引用
袁国跃,董嗣婧,朱天一,钱唯韵,汤冰倩,叶菁菁,张彩丽,宗菁..2型糖尿病合并代谢综合征患者血清chemerin水平与超敏C反应蛋白的相关性[J].江苏大学学报（医学版）,2013,23(4):341-344,4.基金项目
江苏省自然科学基金资助项目(BK2009208) （BK2009208）
江苏省卫生厅国际交流支撑计划及面上科技项目(H201247) （H201247）
镇江市社会发展基金资助项目(SH2012027) （SH2012027）
镇江市医学重点人才资助项目(2010) （2010）
