实用临床医药杂志2013，Vol.17Issue(9)：83-85,90,4.DOI:10.7619/jcmp.201309029
血必净对急性胰腺炎患者血清肿瘤坏死因子-α、白介素-1β及白介素-6质量浓度的影响
Effect of Xuebijing injection on serum concentrations of TNF-α, IL-1β and IL-6in patients with acute pancreatitis
孙长江 1范辉 2葛建彬1
作者信息
- 1. 江苏省南通市第二人民医院,药剂科,江苏南通,226002
- 2. 江苏省南通市第二人民医院,消化科,江苏南通,226002
- 折叠
摘要
Abstract
Objective To investigate the effects of Xuebijing injection on serum concentrations of TNF-α,IL-1β and IL-6 in patients with acute pancreatitis(AP).Method A total of 79 patients were randomly divided into Xuebijing group (n =41) and conventional treatment group (n =55) with 33 healthy volunteers as a control group.ELISA was applied to measure the serum concentration of these cytokine:TNF-α,IL-1β and IL-6 at different time points(1 d,3 d,1 w,2 w after the onset of AP).Results The serum of concentrations of TNF-α,IL-1β and IL-6 reached the maximum on the first day when AP occurred,the serum concentration of TNF-α,IL-1β and IL-6were still at high level at the third day after occurrence compared with the control group (P ＜ 0.05).And at the end of the first week,serum concentration of TNF-α and IL-1β were still higher than the control group (P＜0.05).Compared with the conventional treatment group,serum concentrations of TNF-α of Xuebijing group were significantly decreased from the third day to the seventh day,and the serum concentrations of IL-1β and IL-6 were significantly reduced on the third day (P＜0.05).Conclusion Xuebijing can reduce serum concentrations of TNF-α,IL-1β and IL-6 at the early stage of the AP course.Inhibiting the inflammation may be the molecular mechanisms through which Xuebijing treats AP.关键词
血必净/急性胰腺炎/肿瘤坏死因子-α/白介素-1β/白介素-6Key words
Xuebijing/acute pancreatitis/tumor necrosis factor-α/interleukin-1β/interleukin-6分类
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孙长江,范辉,葛建彬..血必净对急性胰腺炎患者血清肿瘤坏死因子-α、白介素-1β及白介素-6质量浓度的影响[J].实用临床医药杂志,2013,17(9):83-85,90,4.
