实用临床医药杂志2013，Vol.17Issue(13)：48-50,3.DOI:10.7619/jcmp.201313016
新生儿脐带血胰岛素样生长因子-Ⅰ水平与妊娠糖代谢异常母体糖化血红蛋白的关系研究
Study on relationships between insulin-like growth factor-Ⅰ in neonatal umbilical cord blood and HbAlc in the matrix with abnormal gestational glycometabolism
摘要
Abstract
Objective To investigate the correlation between insulin-like growth factor-Ⅰ(IGF-Ⅰ) in neonatal umbilical cord blood and glycosylated hemoglobin (HbAlc) in the matrix with impaired gestational glycometabolism.Methods The puerperal full-term single live-birth women and their puerperal neonates (n=60) were divided into GDM group,GIGT group and normal control group,20 cases in each group.The whole blood of pregnant women was drawn 2 weeks before delivery,and Elisa method was performed to detect the level of serum HbAlc.After the delivery,the umbilical cord was cut off to collect blood,and immunoenzymometric assay at two sites was performed to detect the level of serum IGF-Ⅰ.The relevant analysis was conducted on the levels of HbAlc and IGF-Ⅰ in neonatal umbilical cord blood as well as neonatal birth weight in each group.Results The level of HbAlc in GDM group was obviously higher than that in normal control group (P ＜ 0.05).The level of IGF-Ⅰ and neonatal birth weight in GIGT group were markedly higher than those in normal control group (P ＜ 0.05).The relationships between IGF-Ⅰ and birth weight as well as HbAlc and IGF-Ⅰ in normal control group,IGF-Ⅰ and birth weight in GIGT and GDM groups were remarkably positive (P ＜ 0.05).Conclusion Detection of plasma IGF-Ⅰ in late-pregnancy women can reflect the level of endocrine factor IGF-Ⅰ in fetuses to a certain extent which reflects the intrauterine growth and development of fetuses.关键词
妊娠期糖耐量异常/糖化血红蛋白/胰岛素样生长因子-ⅠKey words
impaired glucose tolerance/ glycosylated hemoglobin/ insulin-like growth factor-Ⅰ分类
医药卫生引用本文复制引用
刘芳,赵宇华,陆洁敏,刘岚..新生儿脐带血胰岛素样生长因子-Ⅰ水平与妊娠糖代谢异常母体糖化血红蛋白的关系研究[J].实用临床医药杂志,2013,17(13):48-50,3.基金项目
中国高校医学期刊临床专项资金(11320129) （11320129）
