摘要
Abstract
Objective To investigate the clinical efficacy of benazepril combined with metoprolol in the treatment of chronic heart failure (CHF).Methods One hundred and twenty-two patients with CHF were randomly divided into treatment group and control group,61 cases in each group.Both groups were given conventional therapy.The treatment group was added benazepril and metoprolol.The heart rate variability (HRV),vascular endothelial diastolic function of brachial artery,plasma brain natriuretic peptide (BNP),six-minute walk trial (6MWT) distance and adverse reactions of patients in two groups were compared.Results After treatment,every indexes of HRV significantly increased,and the increased range of treatment group was obviously larger than that of control group.Both the inner diameter (D1) of brachial artery and its expanding percentage (△) were markedly amplified in two groups during reactive hyperemia,and the amplified range of the treatment group was conspicuously larger than that of the control group.BNP in both groups significantly decreased,6MWT distance was notably prolonged,and the decreased range of BNP and prolonged range of 6MWT distance were larger than those of the control group.All adverse reactions of treatment group were milder.Conclusion Based on conventional therapy,the application of benazepril combined with metoprolol in the treatment of CHF patients can markedly elevate HRV indexes,enhance vascular endothelial diastolic function,decrease plasma BNP level and prolong 6MWT.The adverse reactions are milder,and patients can tolerate,which deserves to be popularized and further researched.关键词
贝那普利/美托洛尔/慢性心力衰竭/心率变异性/内皮功能/脑钠肽Key words
benazepril/ metoprolol/ chronic heart failure/ heart rate variability/ endothelial function/ brain natriuretic peptide分类
医药卫生
