实用临床医药杂志2013，Vol.17Issue(15)：5-7,3.DOI:10.7619/jcmp.201315002
类风湿性关节炎患者血清白介素-33、肿瘤坏死因子-α、C反应蛋白的水平变化及意义
Changes and significance of interleukin-33,tumor necrosis factor-αand C reaction protein levels in patients with rheumatoid arthritis
摘要
Abstract
Objective To explore the changes and significance of interleukin-33 (IL-33),tumor necrosis factor-α(TNF-α) and C reactive protein (CRP) levels in patients with rheumatoid arthritis (RA).Methods Fifty patients with RA were divided into active-stage RA group and non -active stage RA group according to RA active-stage criterion of Chinese Rheumatology Association,25 cases in each group.Thirty healthy people that underwent physical examination in the medical center of our hospital were selected as control group.Collection of 5 mL blood was made from fasting patients in each group in the morning,followed by serapheresis.Serum CRP level was detected by immunoturbidimentry,IL-33 and TNF-α level were examined by double antibody sandwich enzyme linked immunosorbent assay (Elisa).Then serum IL-33,TNF-α and CRP levels in each group were compared,while the correlations between IL-33 and TNF-α as well as between IL-33,TNF-α and CRP in RA group were analyzed.Results Serum IL-33,TNF-α and CRP levels in the RA group were markedly higher than those in the control group.They were also higher in active-stage RA group than in non-active-stage RA group.Serum IL-33 level was in positive correlation with TNF-α,and IL-33 and TNF-α were positively related to CRP level in the RA group.Conclusion Serum IL-33,TNF-α and CRP levels in RA group are of great clinical importance in observing RA pathogenic conditions.关键词
类风湿性关节炎/血清白介素-33/肿瘤坏死因子-α/C反应蛋白Key words
rheumatoid arthritis/ serum interleukin-33/ tumor necrosis factor-α/ C reaction protein分类
医药卫生引用本文复制引用
黄文辉,陈瑞林,曾颖瑜,林泽英..类风湿性关节炎患者血清白介素-33、肿瘤坏死因子-α、C反应蛋白的水平变化及意义[J].实用临床医药杂志,2013,17(15):5-7,3.基金项目
中国高校医学期刊临床专项资金(11321092) （11321092）
