实用临床医药杂志2013，Vol.17Issue(15)：14-16,3.DOI:10.7619/jcmp.201315005
强化阿托伐他汀对老年非ST段抬高型急性冠脉综合征患者介入术中的心肌保护作用
Myocardial protection of strengthening atorvastatin therapy in intervention surgery for elderly patients with non-ST-segment elevation acute coronarysyndrome
王晓华 1刘树琴 1王英丽 1金跃1
作者信息
- 1. 山东省聊城市人民医院,山东聊城,252000
- 折叠
摘要
Abstract
Objective To investigate the myocardial protection of strengthening atorvastatin therapy in intervention surgery for elderly patients with non-ST-segment elevation acute coronarysyndrome.Methods Eighty patients with routine interventional cardiology surgery with nonST segment elevation acute coronary syndrome were selected as research subjects and were randomly divided into study group and control group.The study group was given atorvastatin 40 mg orally before operation,40 mg/d orally.30 d after operation,it was changed to a maintenance dose of 20 mg/d 30d after.The control group was given preoperative and postoperative atorvastatin 20 mg/d treatment.All patients were routinely given secondary prevention of coronary heart disease treatment.Myocardial damage markers of the two groups were compared.Results The postoperative CTnI,CK-MB values significantly increased compared with preoperative ones,the difference being statistically significant (P＜ 0.05).Wherein CTnI,CK-MB values of the control group increased more markedly than the study group (P ＜ 0.05).One day after the operation,CRP levels of both groups increased,but there were no significant difference between them (P ＞0.05).After 7 days,the CRP levels of study group was significantly lower than the control group,the difference being statistically significant (P ＜ 0.05).Pro-BNP of both groups markedly decreased after 7 days.Compared with before the operation,the difference being statistically significant(P ＜ 0.01),and ProBNP of the control group was markedly higher than the study group (P ＜ 0.01).Conclusion Strengthened atorvastatin therapy can reduce myocardial cell damage and inflammation reactions,and is conducive to the patient's recovery.关键词
阿托伐他汀/强化治疗/急性冠脉综合征/非ST段抬高型Key words
atorvastatin/ intensive treatment/ acute coronary syndrome/ non-ST-segment elevation分类
医药卫生引用本文复制引用
王晓华,刘树琴,王英丽,金跃..强化阿托伐他汀对老年非ST段抬高型急性冠脉综合征患者介入术中的心肌保护作用[J].实用临床医药杂志,2013,17(15):14-16,3.
