实用临床医药杂志2013，Vol.17Issue(15)：66-68,3.DOI:10.7619/jcmp.201315024
目标剂量美托洛尔缓释片对慢性心力衰竭患者的影响
Effects of target dose of metoprolol sustained-release tablets on patients with chronic heart failure
摘要
Abstract
Objective To explore effects of target dose of metoprolol sustained-release tablets on the patients with chronic heart failure (CHF).Methods Two hundred and ten patients with CHF were randomly divided into observation group and control group,105 cases in each group.Based on the conventional treatment of heart failyure,the observation group was given target dose of metoprolol sustained-release tablets,while the control group given the fixed small dose.Ten months later,the total efficacy rate,left ventricular ejection fraction (LVEF),left ventricular end systolic volume (LVESV),left ventricular end diastolic volume (LVEDV),a second hospitalization rate and adverse reactions as well as the changes of rest heart rate (RHR),N-terminal B-type natriuretic peptide (NT-proBNP) and 6 min walking test (6 MWT) before and after treatment were compared in the two groups.Results The total efficacy rate of the observation group was markedly higher than that of the control group,while the second hospitalization rate obviously lower,the difference having statistical significance.LVEF and 6 MWT of the observation group were evidently higher than that of the control group,while LVESV,LVEDV,RHR and NT-proBNP conspicuously lower.Conclusion The target dose of metoprolol sustained-release tablets can effectively improve the clinical effect of patients with CHF,ameliorate exercise tolerance,decrease a second hospitalization rate,enhance the quality of life,and its therapeutic effect is superior to the fixed small dose.关键词
慢性心力衰竭/目标剂量/美托洛尔缓释片Key words
chronic heart failure, target dose/ metoprolol sustained-release tablets分类
医药卫生引用本文复制引用
任勇,秦震芳..目标剂量美托洛尔缓释片对慢性心力衰竭患者的影响[J].实用临床医药杂志,2013,17(15):66-68,3.基金项目
中国高校医学期刊临床专项资金(11321064) （11321064）
