口腔颌面外科杂志2013，Vol.23Issue(4)：253-256,4.DOI:10.3969/j.issn.1005-4979.2013.04.004
纳米增韧HA-ZrO2生物陶瓷与骨缺损断面的结合性能观察
Bone Tissue Response to Nano-HA-ZrO2 Compound Bioceramics
孟志兵 1唐月军 2郭军 1吕春堂 3周中华3
作者信息
- 1. 扬州市第一人民医院口腔科,江苏扬州225000
- 2. 苏州卫生职业技术学院,江苏苏州215002
- 3. 第二军医大学长海医院口腔科,上海200433
- 折叠
摘要
Abstract
Objective:The purpose of the present study was to observe the combination of the interface between nanoHA-ZrO2 compound bioceramics and bone tissue.Methods:12 healthy adult New Zealand rabbits were used in the study.Nano-HA-ZrO2 compound bioceramics were placed in one side of the mandible.On the other side,HA were placed as control.Animals were sacrificed at 4、8、12 weeks after operation,histological sections and the interface shear strength were evaluated.X-ray examination were also performed to observe the interface between the bone,nano-HA-ZrO2,and HA bioceramics materials.Results:Hard tissue section and X-rays examination showed a good interface osseointegration appeared at 12 weeks in nano-HA-ZrO2 ceramic group,as well as in HA group.Fibrous tissue manifested in some areas of the interface.Incomplete osseointegration were shown in the interfaces at those 4-and 8-week animals.Interface shear strength of nano-HA-ZrO2 at 4-,8-,12-weeks was (2.36±1.04),(11.65±1.48) and(30.95±3.67)MPa respectively(P＜0.01).While those of HA's was (2.27±1.12),(12.33±1.57) and (31.05±3.44)MPa respectively(P＜0.01).Conclusion:This result demonstrates Nano-HA-ZrO2 compound bioceramics can be integrated into bone section.But how to accelerate integrating rate and acquire complete osseointegration as soon as possible,further studies are needed.关键词
纳米增韧HA-ZrO2生物陶瓷/骨结合/硬组织切片Key words
Nano-HA-ZrO2 bioceramics/osseointegration/sclerous tissues section分类
医药卫生引用本文复制引用
孟志兵,唐月军,郭军,吕春堂,周中华..纳米增韧HA-ZrO2生物陶瓷与骨缺损断面的结合性能观察[J].口腔颌面外科杂志,2013,23(4):253-256,4.
