青岛大学医学院学报2013，Vol.49Issue(3)：202-204,3.DOI:10.11712/qdyxy201303005
MMP-9基因rs17577多态性与脑梗死的关系
CORRELATION BETWEEN GENETIC POLYMORPHISM AT THE rs17577 SITE OF MATRIX METALLOPROTEINASE-9 GENE AND CEREBRAL INFARCTION
摘要
Abstract
Objective To investigate the relationship between the polymorphism of matrix metalloproteinase-9 (MMP-9) gene rs17577 and cerebral infarction (CI) in Han population of Qingdao.Methods The polymorphisms of MMP-9 gene rs17577 in CI patients and normal controls were detected and compared by employing polymerase chain reaction-restriction fragment length polymorphism and gene sequencing.Results The frequency of the GA genotype and A alleles were significantly higher in CI than that in the control group (x2 =8.74,7.79;P ＜0.01).Logistic regression analysis indicated that A allele was associated with the development of CI (OR=1.855,95％CI=1.206-2.854,P＜0.01).Conclusion The genetic polymorphism at the rs17577 site of MMP-9 gene is involved in the pathogenesis of cerebral infarction,and A allele being its risk factor.关键词
脑梗塞/基质金属蛋白酶类/基因型/基因频率Key words
brain infarction/ matrix metalloproteinases/ genotype/ gene frequency分类
医药卫生引用本文复制引用
代伟,曲涛,姜振泼,宋玉强,龙厚元,隋爱华..MMP-9基因rs17577多态性与脑梗死的关系[J].青岛大学医学院学报,2013,49(3):202-204,3.基金项目
山东省自然科学基金资助项目(ZR2009CM136) （ZR2009CM136）
