山东医药2013，Vol.53Issue(26)：30-33,4.DOI:10.3969/j.issn.1002-266X.2013.26.011
结肠癌组织中Bmi-1表达变化及意义
Expression and significance of Bmi-1 in human colon carcinoma
张念华 1宋立兵 2丁娅 3彭瑞清 1曾木圣 2张晓实1
作者信息
- 1. 华南肿瘤学国家重点实验室,广州510060
- 2. 中山大学肿瘤防治中心
- 3. 广东省第二中医院
- 折叠
摘要
Abstract
Objective To examine whether over expression of Bmi-1 is associated with colon carcinoma characteristics,we evaluated Bmi-1 expression in colon tissue and in primary and lymphonode metastatic tissues of different Dukes stages colon carcinoma.Methods Immunohistochemical staining for Bmi-1 was carried out on paraffin-embedded tissues from 64 colon carcinoma patients who had undergone radical surgery.The correlation of Bmi-1 expression to clinicopathologic features of colon carcinoma was analyzed.Results The intensive positive rate of Bmi-1 in colon carcinoma was 62.5％ (40/64),which was 12.5％ (8/64)in the colon tissue beside tumor tissue.Compare with the colon tissue beside tumor tissue,Bmi-1 over expression is common in colon carcinoma (P ＜ 0.05).There was no Bmi-1 expression in colonic polyp tissues.The intensive expression of Bmi-1 was positively correlated to Ducks stage and pathologic grade (P ＜ 0.05).Conclusions The intensive expression of Bmi-1 in colon carcinoma is related to tumor progression.关键词
结肠癌/多梳基因/免疫组化Key words
colon carcinoma/ polycomb gene/immunohistochemical分类
医药卫生引用本文复制引用
张念华,宋立兵,丁娅,彭瑞清,曾木圣,张晓实..结肠癌组织中Bmi-1表达变化及意义[J].山东医药,2013,53(26):30-33,4.
