天然产物研究与开发2013，Vol.25Issue(6)：759-761,791,4.
石参总黄酮对一氧化氮致大鼠胰岛细胞损伤的保护作用
Protective Effect of Total Flavonoids from Urariacrinita Root against Injury of Rat Pancreatic Islet Cells Caused by Nitric Oxide
吴伟斌 1庞建新 1曹莹 1谢宝平 1丘玉昌1
作者信息
- 1. 南方医科大学药学院新药评价中心,广州510515
- 折叠
摘要
Abstract
RIN-m cells were injured by sodium nitroprusside (SNP),adonator of NO.The objective of this study was to evaluate the protective effect of total flavonoids from Urariacrinitaroot (UCRFs) on RIN-m cell.The cell viability,intracellular content of malondiadehyde (MAD) and total glutathione (GSH),as well as total activity of superoxide dismutase (SOD) were measured.The experimental results showed that UCRFs significantly improved the viability of RINm cells injured by SNP,as well as ameliorated the intracellular oxidative stress,which was confirmed by the reduction of intracellular content of MAD.Furthermore,UCRFs increased anti-oxidative ability in INS-1E cells by elevating intracellular GSH content and up-regulating the activity of intracellular SOD.Hence,it was concluded that UCRFs exhibited protective effect against injury caused by NO in RIN-m cells,possibly through the up-regulation of intrinsic anti-oxidative activityof cells.关键词
石参/黄酮/胰岛细胞/一氧化氮Key words
Urariacrinita/ flavonoids/ isletcells/ nitric oxide分类
医药卫生引用本文复制引用
吴伟斌,庞建新,曹莹,谢宝平,丘玉昌..石参总黄酮对一氧化氮致大鼠胰岛细胞损伤的保护作用[J].天然产物研究与开发,2013,25(6):759-761,791,4.
