天然产物研究与开发2013，Vol.25Issue(6)：830-833,4.
生姜提取物对阿尔茨海默病大鼠动物模型的氧化应激因子的影响
Effect of Ginger Root Extract on Oxidative Stress of Alzheimer's Disease Rats
摘要
Abstract
The aim of this study was to investigate the effect of ginger root extract on oxidative stress of Alzheimer's disease (AD) rats which was intervened by β-amyloid protein,and to further explore the therapeutic effect and mechanism of ginger extract on AD.60 healthy rats,including half male and half female,were divided into six groups randomly as follows:OP + GRE low dose group (OP + LG),OP + GRE medium dose group (OP + MG),OP + GRE high dose group (OP + HG),SHAM group (SHAM),OP + HupA group (OP + HupA) and OP group (OP).After gavaging corresponding drugs 4 weeks,the oxidative stress parameters and pathologic changes of rats were determined by immunohistochemical method of superoxide dismutase (SOD),catalase (CAT) and Elisa analysis of malondialdehyde (MDA).The positive expression of CAT and SOD were significantly increased in OP + HG and the OP + HupA group,while MDA levels decreased significantly (P ＜ 0.05 vs OP).The difference was not significant in OP + LG group and OP + MG group compared with OP group.Hence,it was concluded that the high doses of ginger root extract can improve the expression of SOD and CAT positively and reduce the levels of MDA in the AD rat.关键词
阿尔茨海默病/β-淀粉样蛋白/大鼠动物模型/氧化应激Key words
Alzheimer's disease /β-amyloid protein/ animal models of rats / oxidative stress分类
医药卫生引用本文复制引用
曾高峰,张志勇,鲁力,肖德强,宗少晖,何建明..生姜提取物对阿尔茨海默病大鼠动物模型的氧化应激因子的影响[J].天然产物研究与开发,2013,25(6):830-833,4.基金项目
广西卫生厅中医药管理局课题(GZKZ10-104) （GZKZ10-104）
