外科理论与实践2013，Vol.18Issue(4)：340-345,6.DOI:10.3969/j.issn.1007-9610.2013.04.010
乙醛脱氢酶1A1表达与乳腺癌淋巴结转移及预后关系研究
Relationship of expression of ALDH1A1 in breast cancer with lymph node metastasis and prognosis
摘要
Abstract
Objective To analyze the relationship between the expression of ALDH1A1 in breast cancer and the clinical factors.Methods The expression of ALDH1A1 was detected in 72 cases with breast cancer by immunohistochemical method.The relationship between ALDH1A1 expression and clinical characteristics including lymph node metastasis,tumor differentiation,TNM staging and overall survival time was analyzed.Results ALDH1A1 expressed in 21/37 (56.8％) cases of breast cancer with lymph node metastasis and only in 8/35 (22.9％) cases without.ALDH1A1 expression highly correlated with lymph node metastasis (P＜0.01),but no significant relationship existed between ALDH1A1 expression and other clinical factors such as TNM stage,tumor differentiation and receptor status (P＞0.05).Kaplan-Meier analysis showed higher value of overall survival time,disease free survival time,5-year survival rate and 5-year disease free survival rate in the group with lower ALDH1A1 expression (P＜0.05).Both univariate and multivariate analyses showed that ALDH1A1 expression,lymph node metastasis and TNM stage were independent prognostic factors of the patients with breast cancer (P＜0.05).The higher expression of ALDH1A1 indicates a poorer prognosis.Conclusions ALDH1A1 might be a potential biomarker for lymph node metastasis and poorer clinical outcome in breast cancer.关键词
乳腺癌/乙醛脱氢酶1A1/淋巴结转移/预后Key words
Breast cancer/ ALDH1A1/ Lymph node metastasis/ Prognosis分类
医药卫生引用本文复制引用
彭智猷,朱晨芳,戚晓亮,杨雪,顾岩..乙醛脱氢酶1A1表达与乳腺癌淋巴结转移及预后关系研究[J].外科理论与实践,2013,18(4):340-345,6.基金项目
国家自然科学基金(30872521) （30872521）
上海市卫生局青年科研项目(2009Y043) （2009Y043）
