现代妇产科进展2013，Vol.22Issue(8)：635-637,3.
抗苗勒管激素及其Ⅱ型受体与卵母细胞成熟的关系
Relationship between anti-mullerian hormone, anti-mullerian hormone receptor type Ⅱand oocyte maturation
姜宙 1王晓燕 2孙贤华 2邹淑花2
作者信息
- 1. 青岛大学医学院,青岛 266021
- 2. 青岛市妇女儿童医疗保健中心生殖中心,青岛266011
- 折叠
摘要
Abstract
Objective:To investigate the relationship among anti-mullerian hormone (AMH),anti-mullerian hormone receptor type Ⅱ expression and oocyte maturation.Methods:Cumulus granular cells,follicular fluids and blood samples were obtained from 32 ovulatory women undergoing intracytoplasmic sperm injection treatment on ovum pick-up day.All the samples were recorded oocyte maturation and the number of retrieved oocytes.The influence of serum and follicular fluids AMH basal levels were evaluated by ELISA.Cumulus GC were assayed by Realtime PCR for AMHR Ⅱ mRNA expression.Results:AMH concentrations in the FF were higher than that of serum and showed significant differences [(3083.78 ±682.19)pg/ml vs (1012.29±423.21) pg/ml,P＜0.001].AMH concentrations in the FF and serum level of each retrieved oocytes were found positive correlation(P=0.045).AMH concentrations in the FF of M Ⅱ oocytes were significantly lower than in the FF of M Ⅰ oocytes (P =0.000).AMHR Ⅱ mRNA expression in cumulus GC in M Ⅰ oocytes were 4 times more than M Ⅱ oocytes (P =0.000).Conclusion:AMH may inhibit the maturation of oocyte via type Ⅱ receptor.Serum AMH level of each retrieved oocytes could be used as a diagnostic criterion of oocyte maturation.关键词
抗苗勒管激素/抗苗勒管激素Ⅱ型受体/卵母细胞成熟度/卵丘颗粒细胞Key words
Anti-mullerian hormone/Anti-mullerian hormone receptor type Ⅱ/Oocyte Maturation/Cumulus granular cells分类
医药卫生引用本文复制引用
姜宙,王晓燕,孙贤华,邹淑花..抗苗勒管激素及其Ⅱ型受体与卵母细胞成熟的关系[J].现代妇产科进展,2013,22(8):635-637,3.
