现代妇产科进展2013，Vol.22Issue(8)：644-646,650,4.
克罗米芬联合促卵泡素治疗多囊卵巢综合征的疗效观察
Analysis of the effects of clomiphene citrate and clomiphene citrate combined with different follicle stimulating hormone for the induction of ovulation in women with polycystic ovary syndrome
李慧 1李瑾 1李国屏1
作者信息
- 1. 深圳市宝安区妇幼保健院生殖健康科,深圳518133
- 折叠
摘要
Abstract
Objective:To obtain the appropriate ovulation induction plan for women with polycystic ovary syndrome(PCOS) by comparisons of the effects of the three groups for inducing ovulation by means of clomiphene citrate(CC) or clomiphene citrate combined with gonadotropin.Methods:81 PCOS women who attended for treatment on reproductive department in our hospital from Jan.2009 to Jul.2012 were chosen for this study.92 cycles were assessed.CC was given to all the women for 5 days from day 5 initially.Adding rFSH or uFSH for induction of ovulation was decided by the dominant follicle diameter on cycle day 8.Patients were divided into three groups:group A was given CC+HCG (26 cases,32 cycles),group B was given CC+rFSH+HMG+HCG (23 cases,26 cycles)and group C was given CC+uFSH+HMG+HCG (32 cases,34 cycles).Progestin was given to the women for 12 to 14 days in ovulatory cycles for supporting luteum after ovulation.Effects of ovulation induction were compared in the three groups.Result:In group A two cases of LUFS occurred.In group B four cases of mild OHSS occurred.In group C one case of serious OHSS and one case of LUFS occurred.The data of the biggest follicular diameter and uterus intimal thickness on the day HCG administration and the data of ovulation rate and pregnancy rate in the three treatments were not significant (P＞0.05).The dominant follicle diameter on cycle day 8 in group A showed larger than that in the other two groups.The number of the follicle with diameter bigger than 1.5cm and the number of ovulation were larger in group B than in the other two groups.(P＜0.05) The time to the day HCG administration and the total doses of FSH used did not show significant between group B and group C (P＞0.05).Conclusion:The dominant follicle diameter on cycle day 8 may provide reference in the condition of deciding using gonadotropin properly when CC applied in PCOS women.CC combined with uFSH is economical and effective when the cycle may resist CC used only.关键词
克罗米芬/多囊卵巢综合征/促排卵/促卵泡素Key words
Clomiphene citrate/Polycystic ovarian syndrome/Induction of ovulation/Follicle-Stimulating Hormone分类
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李慧,李瑾,李国屏..克罗米芬联合促卵泡素治疗多囊卵巢综合征的疗效观察[J].现代妇产科进展,2013,22(8):644-646,650,4.
