应用化学2013，Vol.30Issue(9)：999-1004,6.DOI:10.3724/SP.J.1095.2013.20541
N-(2-(腈基(4,6-二甲氧基嘧啶-2-基)甲基)苯基)酰胺类衍生物的合成及生物活性
Synthesis and Biological Activities of N-(2-(Cyano(4,6-dimethoxypyrimidin-2-yl) methyl) phenyl)Substitued Amide Derivatives
摘要
Abstract
Six novel N-(2-(cyano (4,6-dimethoxypyrimidin-2-yl) methyl) phenyl) substitued amide derivatives were synthesized using 2-(2-nitrophenyl) acetonitrile and 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine as starting materials by condensation reaction,reduction reaction and acylation reaction,respectively.The structures of all synthesized compounds were determined by 1H NMR,MS and elemental analysis techniques.As-synthesized compounds did not show herbicidal activities at 150 g/hm2.The antibacterial activity test indicated that some of them exhibited certain inhibitory activities against Sphaerotheca fuliginea and Rhizoctonia solani,respectively at 200 mg/L.The inhibition rate of compound 4d against Rhizoctonia solani was 72.3％ at 200 mg/L.关键词
嘧啶水杨酸/二甲氧基嘧啶/酰胺/合成/生物活性Key words
pyrimidinylsalicylic acid/ dimethoxypyrimidine/ amide/ synthesis/ biological activities分类
化学化工引用本文复制引用
李元祥,陈迪钊..N-(2-(腈基(4,6-二甲氧基嘧啶-2-基)甲基)苯基)酰胺类衍生物的合成及生物活性[J].应用化学,2013,30(9):999-1004,6.基金项目
湖南省科技计划项目(2012NK3098),湖南省教育厅科学研究重点项目(11A092),2010年湖南省高校产学研合作示范基地资助项目 （2012NK3098）
