应用化学2013，Vol.30Issue(9)：1005-1009,5.DOI:10.3724/SP.J.1095.2013.20523
六水合三氯化铁催化3-甲基环己酮与丙酮酸乙酯交叉羟醛缩合制备薄荷内酯
Synthesis of Mintlactone via Cross-Aldol Condensation Between 3-Methylcyclohexanone and Ethyl Pyruvate Using Ferric Chloride Hexahydrate as Catalyst
陈雄 1刘金云 1李亚白 1刘建福 1杨华武1
作者信息
- 1. 湖南中烟工业有限责任公司技术中心 长沙410007
- 折叠
摘要
Abstract
A FeCl3·6H2O-catalyzed cross-Aldol condensation of 3-methylcyclohexanone and ethyl pyruvate was developed for the synthesis of mintlactone.The resultant ethyl 2-(4-methyl-2-oxocyclohexylidene)propionate and 7a-hydroxymintlactone were saponified by NaOH,reduced by NaBH4,and acidified to yield (±)-mintlactone in 51％ yield.Regioselectivity of the keto-to-enol isomerization of 3-methylcyclohexanone and isomer ratio of (±)-mintlactone/(±)-isomintlactone in crude products were discussed.关键词
甲基环己酮/丙酮酸乙酯/六水合三氯化铁催化剂/交叉羟醛缩合/薄荷内酯Key words
methylcyclohexanone/ ethyl pyruvate/ ferric chloride hexahydrate catalyst/ cross-Aldol condensation/ mintlactone分类
化学化工引用本文复制引用
陈雄,刘金云,李亚白,刘建福,杨华武..六水合三氯化铁催化3-甲基环己酮与丙酮酸乙酯交叉羟醛缩合制备薄荷内酯[J].应用化学,2013,30(9):1005-1009,5.
