摘要
Abstract
Objective:To study the clinical distribution and drug resistance of Enterobacter cloacae in Changshu area for guiding the rational use of drugs.Me,ods:During 2010-2012,593 strains of Enterobacter cloacae were isolated from inpatients of hospitals in Changshu area.The AmpC β-1actamases (AmpC) and extended spectrum β-lactamases (ESBLs) were detected by modified three-dimensional extract test.Enterobacter cloacae was identified and antimicrobial susceptibility was assayed by VITEK-2 compact all automatic microbiology analysis system.Results:Among the 593 strains of Enterobacter cloacae,51.1％ were isolated from sputum and 24.6％ from urine.Intensive care unit (ICU) and Department of Respiratory Diseases occupied 30.0％ and 33.7％; 30.0％ were ESBLs producing strains,14.3％ were AmpC producing strains,and 8.4％ were both ESBLs and AmpC producing strains.The drug resistance rates to ampicillin,cefazolin,cefoxitin,cefuroxime were 50％-100％,imipenem and meropenem had the lowest resistance rates.The drug resistant rates to piperacillin/tazobactam,cefuroxime,levofloxacin were increasing year by year.Conclusions:Enterobacter cloacae strains often cause respiratory tract infection and urinary tract infection in Changshu area.Multiple drug resistance is serious,and the emergence of carbapenem-resistant isolates should induce clinical attention.Rational selection of antibiotics should be emphasized.关键词
阴沟肠杆菌/药敏试验/β-内酰胺酶/抗菌药物Key words
Enterobacter cloacae/ Drug sensitivity test/ β-lactamases/ Antibiotics分类
医药卫生
