摘要
Abstract
Objective To investigate the risk factors for the progression of early stage Parkinson's disease (PD).Methods One hundred and fourteen early-stage PD patients Hoehn and Yahr stage ＜ 3) were classified using k means cluster analysis and then further divided into the rapid disease progression group and non-rapid disease progression group based on disease progression.The demographic data,motor variables,MMSE,HAMD,PQSI,FSS score were compared between groups.The relationships between PD progression and demographic data,motor variables,MMSE,HAMD,PQSI,FSS score were analyzed by using spearman rank correlation.Logistic regression analysis was applied to determine the risk factors for PD progression.Results Twenty-six patients were divided into the rapid disease progression group,and 88 into the non-rapid disease progression group based on disease progression.Age,age of disease onset,the mean score of UPDRS Ⅲ rigidity,bradykinesia,and postural instability/gait difficulties (PIGD),UPDRS Ⅱ,UPDRS Ⅱ/disease duration,HAMD score of patients in rapid disease progression group were significantly greater than those in the non-rapid disease progression group (P ＜0.05).Spearman rank correlation showed UPDRS Ⅰ-Ⅲ/disease duration had significant correlation with age of disease onset,disease duration,the mean score of UPDRS Ⅲi rigidity,bradykinesia,PIGD and HAMD score.Logistic regression analysis showed that odds ratio of age of disease onset and the mean score of UPDRS Ⅲ rigidity were 1.109 and 2.490 (P ＜0.05),respectively.Conclusion The risk factors for the progression of early stage Parkinson's disease may include motor subtypes (dominant rigidity,bradykinesia,and postural instability/gait difficulties),later disease onset and depression.关键词
帕金森病/运动障碍/年龄/抑郁Key words
Parkinson's disease/dyscinesia/age/depression分类
医药卫生
