中国实用内科杂志2013，Vol.33Issue(8)：639-643,5.
支气管哮喘与慢性荨麻疹黏膜免疫介质相关性研究
Humoral and haemal mucosal immunotransmitters in patients co-infected with bronchial asthma and chronic urticaria
摘要
Abstract
Objective To investigate the common pathology and mucosal immune connection between bronchial asthma and chronic urticaria through determination of secretory immunoglobulin-A (sIgA) in the saliva,sputum and nasal secretions as well as CD4 +,CD8 +T lymphocyte,eosinophil cationic protein(ECP) and immunoglobulin E(T-IgE) in the blood of patients co-infected with bronchial asthma and chronic urticaria.Methods One hundred and sixty-five subjects were divided into 4 groups according to their diagnoses:Asthma Group (n =71) ; Urticaria Group (n =31) ; Combined Group (n =33 ; with bronchial asthma and chronic urticaria) ;and Control Group(n =30).sIgA in the sputum,saliva,nasal secretion and T-IgE,ECP in the blood were determined using ELISA ; CD4 + and CD8 + T lymphocytes in the blood were measured using flow cytometry.Results (1) sIgA in saliva and nasal secretion were higher in Asthma,Urticaria,and Combined Groups than in Control group(P ＜ 0.05) ;sIgA in saliva of the urticaria group was increased compared with that of the Combined Group (P ＜0.05),but compared among the three groups of patients,sIgA in nasal secretion was not statistically significant (P ＞ 0.05).sIgA in sputum was lower in Asthma and Combined groups than in Control group and Urticaria Group(P ＜ 0.05) ;comparison between the urticaria group and the normal group had no difference (P ＞ 0.05).(2) CD4 +,CD4 +/CD8 +,T-IgE and ECP were higher in Asthma Group,Urticaria Group,and Combined Group than in Control Group (P ＜ 0.05),but the comparison among the three groups of patients was not statistically significant(P ＞0.05).There was no difference in CD8+ levels among four groups (P ＜ 0.05).(3) Except the sIgA content in saliva and sputum of the normal group,which showed negative correlation (r =-0.369,P =0.045),the sIgA distribution in secretion of samples of the other three groups had no correlation.(4)Except the T-IgE and ECP levels in blood of the Asthma Group were positively correlated(r ＝0.392,P =0.002),other three groups had no correlation.Conclusion IgA,CD4 +,CD8 +,T-IgE and ECP levels are affected in both asthmatics and patients with urticaria,suggesting mucosal immune transmitters might be a connection between the two diseases.These findings suggest bronchial asthma and urticaria might be part of the same pathology in different locations.关键词
支气管哮喘/慢性荨麻疹/黏膜免疫/分泌性免疫球蛋白A/嗜酸阳离子蛋白Key words
bronchial asthma/chronic urticaria/mucosal immunity/secretory immunoglobulin-A/eosinophil cationic protein分类
医药卫生引用本文复制引用
李风森,张艳丽,徐丹,苏军,王惠妩,向阳冰,孙奇..支气管哮喘与慢性荨麻疹黏膜免疫介质相关性研究[J].中国实用内科杂志,2013,33(8):639-643,5.基金项目
新疆维吾尔自治区自然科学基金(2009211A21) （2009211A21）
