中国实用外科杂志2013，Vol.33Issue(8)：631-634,4.
不可切除结直肠癌肝转移的转化性治疗策略
Convertible therapy for unresectable colorectal liver metastases
朱德祥 1任黎 1许剑民1
作者信息
- 1. 复旦大学附属中山医院普外科复旦大学普通外科研究所复旦大学大肠癌研究中心,上海200032
- 折叠
摘要
Abstract
Surgery is the most effective and the only potentially curative treatment for colorectal liver metastases (CRLM).However,most patients with CRLM are not suitable for liver resection.In recent years,a variety of cytotoxic drugs and/or targeted drugs were used to shrink unresectable liver metastases,and some patients were converted to resectable.Thereby they might be cured following surgical resection.Therefore the purpose of convertible chemothrapy is to get the best response rate,not the maximum response rate.It should choose efficient convertible chemotherapy with short courses for preoperative chemotherapy.For KRAS wild-type patients,cetuximab combined with FOLFOX/FOLFIRI,in which 5-fluorouracil is continuous infused,is recommended,and for KRAS-mutant patients,bevacizumab combined with two-drug chemotherapy regimen or three-drug chemotherapy regimen is considered.They should be operated as soon as the metastases become resectable.关键词
结直肠癌肝转移/不可切除/转化性治疗/化疗/靶向治疗Key words
colorectal liver metastases/ unresectable/ convertible therapy/ chemotherapy/ targeted therapy分类
医药卫生引用本文复制引用
朱德祥,任黎,许剑民..不可切除结直肠癌肝转移的转化性治疗策略[J].中国实用外科杂志,2013,33(8):631-634,4.
