黄玲 1陈路佳 1刘立立 1唐榕 1陈姝 1胡正波1
作者信息
摘要
Abstract
OBJECTIVE:To evaluate the effectiveness and safety of Shugan jieyu capsules in the treatment of mild to moderate depression.METHODS:Retrieved from Cochrane library,EMbase,PubMed,CNKI,CBM,VIP,Wanfang database,RCT about Shugan jieyu capsules in the treatment of mild to moderate depression were collected.2 reviewers independently retrieved the literatures according to the inclusion and exclusion criteria,evaluated the methodological quality of included trials,and extracted data.The data analysis was performed by Rev Man 5.14 software.RESULTS:A total of 15 RCT were included,involving 1240 patients.Results of Meta-analysis showed that total effective rate of Shugan jieyu capsule group was higher than control group in the treatment of mild to moderate depression,there was no statistical significance between 2 groups [OR=1.35,95％ CI(0.89,2.07),P =0.16]; HAMD score of Shugan jieyu capsule group was better than that of control group [MD =-1.39,95 ％ CI (-2.52,-0.26),P=0.02],and the incidence of ADR in Shugenjieyu capsule group was also better than in control group [OR=0.44,95％CI(0.26,0.73),P＜0.01].There was statistical significance.CONCLUSIONS:Shugan jieyu capsule is effective and has good safety in the treatment of mild to moderate depression.However,due to the quality of included studies,more large-scale high-quality RCT are needed.关键词
舒肝解郁胶囊/抑郁症/随机对照试验/系统评价Key words
Shugan jieyu capsule/Depression/Randomized controlled trial/Systematic review分类
医药卫生
