中国药理学与毒理学杂志2013，Vol.27Issue(3)：363-366,4.DOI:10.3867/j.issn.1000-3002.2013.03.010
黄芪配伍熟地对去势大鼠骨质疏松的治疗作用
Effect of Radix Astragali combined with prepared Radix Rehmanniae root on osteoporosis in ovariectomized rats
摘要
Abstract
OBJECTIVE To observe the effect of Radix Astragali combined with prepared Radix Rehmannia root on bone density and pathologic changes of ovariectomized rats.METHODS The osteoporosis model was made by cut off the bilateral ovaries of nonfertile rats.According to the group,ovariectomized rats were respectively intragastrically administered Radix Astragali (5.4 g· kg-1),prepared rehmannia root (5.4 g·kg-1),Radix Astragali combined with prepared rehmannia root(each 2.7 g· kg-1),and nilestriol(0.18 mg·kg-1).16 weeks later,rats were killed and bone slices were made.Measure bone density and pathologic changes of the 2nd lumbar vertebra observed.RESULTS In comparison with sham-operated group,The ovariectomized group gained in body mass obviously,but reducing the mass of thigh-bone (1.05 ±0.11)g evidently and cutting down the bone mass distinctly (P＜0.05).Compared with ovariectomized control group,body mass in Radix Astragali group [(373 ±63)g],prepared rehmannia root group [(370 ± 46) g],Radix Astragali combined with prepared rehmannia root group [(370 ±60)g] increased obviously(P＜0.05),but the mass of thigh-bone was without significant change(P ＞0.05).And Radix Astragali combined with prepared rehmannia root group could obviously increase the bone density of thigh-bone [(0.147 ±0.037)g·cm-1] and vertebra [(0.135 ±0.040)g·cm-1](P＜0.05).And it also can broaden the thickness of the bony cortex [(0.852 ±0.151)g·cm-1] and the diameter of bone trabecula [(0.073 ±0.015)g·cm-1].CONCLUSION Prepared rehmannia root could increase the bone density,promote bone formation and improve bone quality.And it has therapeutic effects on ovariectomized rats with osteoporosis.关键词
黄芪/熟地/绝经后骨质疏松/骨密度Key words
Radix Astragali/ prepared Radix Rehmannia root/ postmenopausal osteoporosis/ bone density分类
医药卫生引用本文复制引用
欧莉,卫培峰,苗彦霞..黄芪配伍熟地对去势大鼠骨质疏松的治疗作用[J].中国药理学与毒理学杂志,2013,27(3):363-366,4.基金项目
The project supported by Education Bureau Foundation of Shaanxi Province (11JK0695) （11JK0695）
陕西省教育厅课题(11JK0695) （11JK0695）
