摘要
Abstract
Objective To investigate the value of ultrasound and serological screening for early diagnosis of down syndrome in early pregnancy.Methods Clinical data of 2522 pregnant women with 9 to 14 weeks of pregnancy were retrospectively analyzed from August 2004 to August 2012 in our hospital.Maternal serum pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (F β hCG) were detected by time-resolved fluorescence immunoassay,and the film thickness of nuchal translucency (NT) was detected by ultrasound.Results Among 2522 pregnant women,serology positive rate was 4.3％,the detection rate was 66.7％.NT-positive rate was 1.0％,the detection rate was 66.7％.Positive rate for combination of two methods was 4.5％,the detection rate was 100％.Serological combined with color Doppler ultrasound NT examination could improve the detection rate.113 positive cases by serology and color ultrasonic NT check,there were 14 cases for abnormal karyotype,4 cases for DS karyotype,10 cases for other abnormal chromosome karyotypes.About 113 cases for down syndrome screening high-risk,there were 44 cases for adverse outcomes,accounting for 38.9％ (44/113),about 2409 cases for screening low-risk,there were 201 cases for adverse outcomes,accounting for 8.1％ (201/2409),there was statistical significant difference (x 2=115.19,P＜0.01).Conclusion PAPP-A,F β-HCG and ultrasonic measurement fetal neck NT can not only improve the DS detection rate in pregnant women in early pregnancy,but also has guiding significance for pregnancy outcomes.关键词
早孕期/唐氏综合征/妊娠相关血浆蛋白A(PAPP-A)/游离β-人绒毛膜促性腺激素(Fβ-HCG)/超声/血清学Key words
Early pregnancy/Down syndrome/Pregnancy-associated plasma protein A (PAPP-A)/Free beta-human chorionic gonadotropin (F β-HCG)/Ultrasound/Serological
