基础医学与临床2011，Vol.31Issue(2)：134-138,5.
脂联素受体在人肾上腺皮髓质及其肿瘤中的不同表达
The mRNA expression of adiponectin receptor 1 and 2 in human adrenal tissues and tumors
摘要
Abstract
Objective To compare the mRNA expression of adiponectin receptor 1 and adiponectin receptor 2 (Adipo R1/R2) in human adrenal tissues and tumors. Methods Total RNA was exracted from 6 normal human adrenal glands, 10 cortisol-secreting tumors, 20 pheochromacytomas and 14 aldosteronomas. We used RT-PCR to compare the mRNA expression of Adipo R1/R2 in human adrenal tissues and tumors and analyzed the relationship between Adipo RI/R2, the GLUAUc and INSAUC of 3 h OGTT. Results The mRNA expressions of AdipoR1/GAPDH and AdiPOR2/GAPDH were significantly lower in normal human adrenal cortex than that in aldosteronoma and cortisol-secreting tumors(P ＜0. 01 ). The mRNA expressions of AdipoR1/GAPDH in pheochromacytomas were higher than that in normal human adrenal medulla(P ＜0. 01 ). The mRNA expressions of AdipoR2/GAPDH in aldosteronoma were lower than cortisol-secreting tumors ( P ＜ 0. 05 ), Adipo R1 positively correlated with Adipo R2 ( r = 0. 335, P ＜ 0. 01 ),Adipo R2 positively correlated with GLUAUc(r =0. 633 ,P ＜0. 001 ). Conclusion Adiponectin was expressed in adrenal tissues, the difference may be explained by the plasma adiponectin.关键词
脂联素受体1/脂联素受体2/肾上腺肿瘤/mRNAKey words
adiponectin receptor 1/ adiponectin receptor 2/ adrenal tumors/ mRNA分类
医药卫生引用本文复制引用
陈适,曾正陪,李汉忠,童安莉,卢琳,宋爱羚,李明..脂联素受体在人肾上腺皮髓质及其肿瘤中的不同表达[J].基础医学与临床,2011,31(2):134-138,5.基金项目
国家科技十五攻关计划(2004BA720A29) （2004BA720A29）
