基础医学与临床2011，Vol.31Issue(2)：155-160,6.
CDMP和TGF联合诱导BMSCs修复软骨缺损
Repairing defects with bone marrow mesenchymal stem cell inducted by CDMP and TGF-β1
摘要
Abstract
Objective Clinical application of implanatation of BMSCs in PLGA scafford and induced by cartilagederived morphogenetic protein 1 (CDMP1) and transforming growth factor-β1 (TGF-β1) to repair defects of cartilage. Methods Under the culture of high-density cell suspension and PLGA frame, BMSCs were observed the ability to repair cartilage combined with PLGA before and after the induction of CDMP and (or) TGF-β1. The complex was implanted into animals and the culturing system was analyzed at the gross level, the histological expression to see the ability to repair cartilage defects. Results The culture system was induced to express cartilagespecific matrix collagen Ⅱ and GAG. The culturing system could repair cartilage defects effectively after transplanted into animals. Conclusion The BMSCs and PLGA complex induced by CDMP1 and TGF-β1 can repair cartilage defects more effectively than the BMSCs and PLGA complex induced by CDMP1 or TGF-β1 only.关键词
骨髓间充质干细胞/软骨源性形态发生蛋白1/转化生长因子-β1/聚乳酸/羟基乙酸共聚物/软骨分化Key words
bone marrow mesenchymal stem cells/ cartilage-derived morphogenetic protein-1/ transforming growth factor-β1/ polylactic acid/glycolic acid copolymer/ chondrogenic differentiation分类
医药卫生引用本文复制引用
崔颖,马林祥,朱丽明,潘欣宇,王雪峰,张本..CDMP和TGF联合诱导BMSCs修复软骨缺损[J].基础医学与临床,2011,31(2):155-160,6.基金项目
辽宁省自然科学基金(20062198) （20062198）
辽宁省教育厅创新团队项目(LT2010063) （LT2010063）
辽宁省教育厅创新团队项目(2007T110) （2007T110）
