基础医学与临床2011，Vol.31Issue(2)：174-178,5.
腺苷对豚鼠左心室流出道自律细胞的电生理效应
Electrophysiological effects of adenosine on pacemaker cells in guinea-pig left ventricular outflow tract
摘要
Abstract
Objective To investigate the effects ot adenosine on spontaneous action potentials of left ventricular outflow tract and the effects of adenosine on epinephrine, hypoxia and acidosis.Methods By using conventional intracellular microelectrode technique to record action potentials, adenosine was used to study the electrophysiological effects on pacemaker cells in ventricular outflow tract.The effects of adenosine on epinephrine, hypoxia and acidosis were also studied.Results ( 1 ) Adenosine significantly decreased the electric activities of pacemaker cells in guinea pig left ventricular outflow tract.(2)10 μmol/L epinephrine resulted in a significant increase in the autorhythmicity of left ventricular outflow tract.50 μmol/L adenosine inhibited the effects of epinephrine notably.(3) Hypoxia and acidosis led to a marked decrease in the autorhythmicity of left ventricular outflow tract.50 μmol/L adenosine led to a notably decrease in the effects of hypoxia and acidosis.Conclusion Adenosine may significantly decrease the autorhythmicity of left ventricular outflow tract and alter the effects of epinephrine, hypoxia and acidosis.关键词
腺苷/左心室流出道/自律细胞/电生理效应Key words
adenosine/ left ventricular outflow tract/ pacemaker cells/ electrophysiological effects分类
生物科学引用本文复制引用
赵兰平,李建东,商爱民,牛欣..腺苷对豚鼠左心室流出道自律细胞的电生理效应[J].基础医学与临床,2011,31(2):174-178,5.基金项目
河北省科学技术研究与发展计划(062761880) （062761880）
