基础医学与临床2011，Vol.31Issue(2)：210-213,4.
ARE——基因表达转录后调控的重要元件之一
The AU-rich element, an important element of post-transcriptional regulation
摘要
Abstract
The adenine and uridine-rich elements(AREs) are found in the 3' untranslated region(3'-UTR) of certain messenger RNAs(mRNAs).AREs have been shown to decrease the stability of mRNAs in which they reside,they can also increase the stability of some mRNAs.ARE binding proteins (ARE-BPs) and the P38 mitogen-activated protein kinase (MAPK) pathway play important roles in regulating the stability of ARE-mRNAs.MicroRNAs (miRNAs) pathway may interact with AREs.关键词
AU元件/mRNA稳定性/ARE结合蛋白/P38 MAPK信号通路/miRNAKey words
adenosine and uridine rich elements (AREs)/ mRNA stability/ ARE bingding protein (ARE-BPs)/ P38 MAPK pathyway/ miRNA分类
医药卫生引用本文复制引用
金佳丽,徐运,张伟云..ARE——基因表达转录后调控的重要元件之一[J].基础医学与临床,2011,31(2):210-213,4.基金项目
国家重点基础研究发展计划(973计划)(2009CB521906) （973计划）
江苏省自然科学基金(BK2009037) （BK2009037）
