基础医学与临床2011，Vol.31Issue(2)：222-224,3.
疼痛的分子生物学研究新进展
Update in molecular mechanism of pain
马璐璐 1刘薇 1黄宇光1
作者信息
- 1. 中国医学科学院,北京协和医学院,北京协和医院,麻醉科,北京,100730
- 折叠
摘要
Abstract
Neuropathic pain is a chronic illness affecting millions of people worldwide, and current treatments are often inadequate, ineffective or accompanied with potential severe side effects.A great deal of researches in the past decade have demonstrated the activation of glial constitutes a vital signaling network between pre-synaptic neurons and post-synaptic neurons, contributing to the release of cytokines, chemtaxin, proinflammatory factors and tumor necrosis factor, facilating the kinase pathways and finally leading to the activation of neurons.Clinical manifestations include hyperalgesia and allodynia.However further identification of pain mechanism, especially its molecular mechanism will help us find the new approach for pain management.关键词
疼痛/钠通道/小胶质细胞/细胞外信号调节MAP激酶类Key words
pain/ sodium channel/ microglia/ extracellular signal-regulated MAP kinases分类
医药卫生引用本文复制引用
马璐璐,刘薇,黄宇光..疼痛的分子生物学研究新进展[J].基础医学与临床,2011,31(2):222-224,3.
