基础医学与临床2011，Vol.31Issue(3)：286-290,5.
UCP1蛋白和UCP3基因表达减少与OLETF鼠早期肥胖有关
UCP1 and UCP3 play an important role in the early stage of the development of obesity in OLETF rats
金成吉 1王晓梅 1李湘 1母义明2
作者信息
- 1. 大连大学附属中山医院内分泌科,辽宁大连116001
- 2. 中国人民解放军总医院内分泌科,北京100039
- 折叠
摘要
Abstract
Objective To investigate the relationship between the body weight change and the mRNA or protein expression of uncoupling proteins (UCPs) in OLETF rats. Methods Body weight was measured weekly. UCP1 protein expression in brown adipose tissue was detected by Western blot, while UCP2 and UCP3 mRNA expression in skeletal muscle was measured by Northern hybridization. Results OLETF rats gained weight with a faster rate than LETO rats, and the difference in the rate of weight gain was most prominent around 9 weeks of age. UCP1 protein level was 1.9-fold higher in LETO than OLETF rots at 10 weeks of age (P ＜ 0. 05 ). UCP3 mRNA level was 5. 5-fold higher in LETO than OLETF rats at 10 weeks of age ( P ＜ 0. 01 ). Conclusion UCP1 and UCP3 expression may play an important role particularly in the early stage of the development of obesity in OLETF rats.关键词
肥胖/UCP1/UCP2/UCP3Key words
obesity/ UCP1/ UCP2/ UCP3分类
医药卫生引用本文复制引用
金成吉,王晓梅,李湘,母义明..UCP1蛋白和UCP3基因表达减少与OLETF鼠早期肥胖有关[J].基础医学与临床,2011,31(3):286-290,5.
