国际医药卫生导报2013，Vol.19Issue(21)：3268-3273,6.DOI:10.3760/cma.j.issn.1007-1245.2013.21.009
培美曲塞联合顺铂在局部晚期肺腺癌同步放化疗中的临床研究
Clinical study of pemetrexed combined with cisplatin concurrent chemoradiotherapy in locally advanced adenocarcinoma of lung
摘要
Abstract
Objective To evaluate short-term effect and acute adverse reactions of pemetrexed combined with cisplatin concurrent chemoradiotherapy in locally advanced adenocarcinoma of lung.Methods 18 patients with locally advanced adenocarcinoma of lung received concurrent chemoradiotherapy(pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 were administrated to patients on the first day of every 3 weeks for 2 cycles),part of the patients were administrated neoadjuvant chemotherapy for 1-2 cycles.Radiotherapy adopted IMRT with a total of 60-70 Gy,1.8-2 Gy/f,5 times per week.Results There were 3 cases of CR,12 cases of PR,2 cases of SD,1 case of PD.The overall response rate (CR + PR) was 83.4％ and the clinical benefiting rate (CR + PR + SD) was 94.5％.The main adverse effects were radioactive esophagitis,bonemarrow suppression and mild gastrointestinal toxicit,tolerated by patients with support treatment.Conclusions Pemetrexed combined with cisplatin concurrent chemoradiotherapy in locally advanced adenocarcinoma of lung has good short-term effect,safety and tolerability.Long-term survival and late complications need further observation.关键词
培美曲塞/顺铂/化疗/非小细胞肺癌/放射疗法/适形/调强/同步放化疗Key words
Pemetrexed/ Cisplatin/ Chemotherapy/ Non-small cell lung cancer/ Radiotherapy/Conformal/ Intensity-modulated/ Concurrent chemoradiotherapy引用本文复制引用
蒋军,黄荣,邓燕明,冯卫能,曾晓红,梁少强,何翰,周菲菲..培美曲塞联合顺铂在局部晚期肺腺癌同步放化疗中的临床研究[J].国际医药卫生导报,2013,19(21):3268-3273,6.基金项目
2011年佛山市科技攻关项目(20111021010043) （20111021010043）
